Treatment Failure after Multiple Courses of Triclabendazole among Patients with Fascioliasis in Cusco, Peru: A Case Series

A concerning trend of triclabendazole treatment failure emerges in the Andes, as documented by seven cases of human fascioliasis in Cusco, Peru. Despite multiple doses (10 mg/kg per dose), patients continued to excrete Fasciola eggs, suggesting potential resistance development. The study employed rapid sedimentation and Kato Katz tests post-treatment to confirm egg persistence. These findings challenge the long-standing efficacy of triclabendazole, a cornerstone in fascioliasis management, and raise alarms for public health interventions in endemic regions like Cusco.

Cabada, M. M., Lopez, M., Cruz, M., Delgado, J. R., Hill, V., & White, A. C. (2016). Treatment Failure after Multiple Courses of Triclabendazole among Patients with Fascioliasis in Cusco, Peru: A Case Series. PLOS Neglected Tropical Diseases, 10(1), e0004361. https://doi.org/10.1371/journal.pntd.0004361