Genetics of Genome-Wide Recombination Rate Evolution in Mice from an Isolated Island

Research on wild house mice from Gough Island reveals that genome-wide recombination rate evolution is not directional and proceeds from distinct genetic loci. The study identified four quantitative trait loci (QTL) influencing recombination rates, with one exhibiting effects opposite to parental trait differences. By analyzing 240 F2 male mice from intercrosses between Gough Island-derived mice and the wild-derived inbred strain WSB/EiJ, scientists quantified autosomal recombination rates using immunofluorescence cytology. Candidate genes and mutations were pinpointed by integrating whole-genome sequencing data with spermatocyte transcriptomic profiles. These findings challenge the assumption that recombination rate evolution follows a predictable pattern, offering new insights into genetic diversity and adaptation in isolated populations.

Wang, R. J., & Payseur, B. A. (2017). Genetics of Genome-Wide Recombination Rate Evolution in Mice from an Isolated Island. Genetics, 206(4), 1841–1852. https://doi.org/10.1534/genetics.117.202382