Case–Case Analysis Using 7 Years of Travelers' Diarrhea Surveillance Data: Preventive and Travel Medicine Applications in Cusco, Peru

Travelers to Cusco, Peru, are at significant risk of severe travelers' diarrhea (TD), with norovirus (NV) being the leading cause, responsible for over 14% of cases and confining most infected individuals to bed. A case–case analysis of seven years of surveillance data revealed that NV, enterotoxigenic Escherichia coli, and ciprofloxacin-resistant Campylobacter were the most prevalent pathogens among adult travelers from high-income countries. Notably, consumption of the local beverage 'chicha' was linked to Cryptosporidium infection. The study highlights the need for destination-specific preventive interventions, such as vaccines targeting these pathogens, to mitigate TD burden in travelers.

Jennings, M. C., Tilley, D. H., Ballard, S.-B., Villanueva, M., Costa, F. M., Lopez, M., Steinberg, H. E., Luna, C. G., Meza, R., Silva, M. E., Gilman, R. H., Simons, M. P., Maves, R. C., & Cabada, M. M. (2017). Case–Case Analysis Using 7 Years of Travelers’ Diarrhea Surveillance Data: Preventive and Travel Medicine Applications in Cusco, Peru. The American Society of Tropical Medicine and Hygiene, 96(5), 1097–1106. https://doi.org/10.4269/ajtmh.16-0633