Synthesis of Axially Chiral 1,1′‐Binaphthalenes by Palladium‐Catalysed Cross‐Coupling Reactions of Triorganoindium Reagents (Eur. J. Org. Chem. 13/2013)

Researchers have developed a highly versatile and enantioselective synthesis of axially chiral 1,1′-binaphthalenes using palladium-catalyzed cross-coupling reactions with triorganoindium reagents. This method allows for the transfer of three groups attached to the indium atom, offering significant flexibility in molecular design. The study highlights that the best enantiomeric excesses are achieved using (R,S)-PPFA as a chiral ligand, enabling precise control over the stereochemistry of the products. Conducted against the backdrop of the Tower of Hercules, Spain's oldest lighthouse and a UNESCO World Heritage Site, this work advances synthetic organic chemistry by providing a robust approach to generating complex chiral molecules with potential applications in pharmaceuticals and materials science.

Mosquera, Á., Pena, M. A., Pérez Sestelo, J., & Sarandeses, L. A. (2013). Synthesis of Axially Chiral 1,1′‐Binaphthalenes by Palladium‐Catalysed Cross‐Coupling Reactions of Triorganoindium Reagents (Eur. J. Org. Chem. 13/2013). European Journal of Organic Chemistry, 2013(13). Portico. https://doi.org/10.1002/ejoc.201390033