Metabolite profiling and biological activities of bioactive compounds produced by Chrysosporium lobatum strain BK-3 isolated from Kaziranga National Park, Assam, India

Researchers have identified two bioactive compounds, α, β-dehydrocurvularin and curvularin, produced by the fungus Chrysosporium lobatum strain BK-3 from Kaziranga National Park. These compounds exhibit distinct biological activities: curvularin shows significant acetylcholinesterase (AChE) inhibitory activity (80%), suggesting potential for treating neurodegenerative conditions like Alzheimer's, while α, β-dehydrocurvularin demonstrates strong cytotoxicity against human tumor cell lines and superoxide anion scavenging activity with an EC50 of 16.71 μg/ml. Molecular docking studies further elucidated the ligand-receptor interactions of curvularin. The study highlights the differential bioactive profiles of these compounds, likely due to minor structural differences, marking a first report of such activities from this fungal strain.

Kumar, C. G., Mongolla, P., Sujitha, P., Joseph, J., Babu, K. S., Suresh, G., Ramakrishna, K. V. S., Purushotham, U., Sastry, G. N., & Kamal, A. (2013). Metabolite profiling and biological activities of bioactive compounds produced by Chrysosporium lobatum strain BK-3 isolated from Kaziranga National Park, Assam, India. SpringerPlus, 2(1). https://doi.org/10.1186/2193-1801-2-122