Synergy between Genome Mining, Metabolomics, and Bioinformatics Uncovers Antibacterial Chlorinated Carbazole Alkaloids and Their Biosynthetic Gene Cluster fromStreptomyces tubbatahanensissp. nov., a Novel Actinomycete Isolated from Sulu Sea, Philippines

Researchers have discovered antibacterial chlorinated carbazole alkaloids and their biosynthetic gene cluster from Streptomyces tubbatahanensis, a novel actinomycete isolated from Tubbataha Reefs Natural Park, a UNESCO World Heritage Site in the Sulu Sea. This finding highlights the untapped potential of marine microorganisms for antibiotic discovery. The study employed a synergistic approach combining genome mining, metabolomics, and bioinformatics to uncover the biosynthetic richness of this novel species, revealing new natural products with significant antibacterial activity.

Tenebro, C. P., Trono, D. J. V. L., Balida, L. A. P., Bayog, L. K. A., Bruna, J. R., Sabido, E. M., Caspe, D. P. C., de Los Santos, E. L. C., Saludes, J. P., & Dalisay, D. S. (2023). Synergy between Genome Mining, Metabolomics, and Bioinformatics Uncovers Antibacterial Chlorinated Carbazole Alkaloids and Their Biosynthetic Gene Cluster fromStreptomyces tubbatahanensissp. nov., a Novel Actinomycete Isolated from Sulu Sea, Philippines. Microbiology Spectrum, 11(2). https://doi.org/10.1128/spectrum.03661-22