Polymorphism Study of the Insulin Receptor Substrate IRS1 and IRS2 Genes Associated with Type 2 Diabetes in Ethnic Groups of Djerba Island

A study on Djerba Island, Tunisia, found no association between specific genetic variants (Gly972 Arg and Ala513Pro in IRS1, Gly1057 Asp in IRS2) and type 2 diabetes mellitus (T2DM) in Arab and Berber ethnic groups. The research compared genotype and allelic frequencies between T2DM patients and healthy controls using Restriction Fragment Length Polymorphism (RFLP) analysis. Despite examining these insulin receptor substrate gene polymorphisms, no significant differences were observed, suggesting these variants do not contribute to T2DM risk in the studied populations.

(Ed.). (2010). Polymorphism Study of the Insulin Receptor Substrate IRS1 and IRS2 Genes Associated with Type 2 Diabetes in Ethnic Groups of Djerba Island. Clinical Medicine Reviews in Vascular Health, 2, 185–190. https://doi.org/10.4137/cmrvh.s3378